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Immune-related pathologic response criteria (irPRC) is a standardized, universal scoring system for assessing pathologic response to immunotherapy, inclusive of immune-mediated tumor regression ( In our study, all patients received scheduled surgery within 29-42 days of initiating imiquimod therapy, demonstrating the feasibility of neoadjuvant imiquimod therapy without delay in surgery

Damage of inner membrane proteins involved in binding oriC, however, can result in a loss of this association and consequently, loss of DNA synthesis [257]

The 100 x 500mcg format translates this approach into precise dosing units, suited to research protocols exploring the digestive rather than systemic route

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