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The peptide was originally characterized by the Sikiric group at the University of Zagreb School of Medicine and has been investigated for over two decades in preclinical research models for its effects on tissue regeneration, angiogenesis, fibroblast migration, and cellular signaling across tendon, ligament, muscle, gastrointestinal, and vascular tissues

doi: 10.1016/j.lfs.2011.01.015

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Proc Natl Acad Sci U S A 1989;86:39537.ArticlePubMedPMC 29

To improve the local resolution of CTR-RAMP extracellular domains (ECDs), focused refinements (masking around receptors or ECD domains) were performed