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Months or even years after a viral infection, many individuals find themselves trapped in a bewildering maze of debilitating symptoms, battling what we now recognize as Long COVID or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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PNP, an enzyme that is part of the nucleotide metabolism via degradation of deoxyguanosine, is involved in NR metabolism in mammalian cells by metabolizing NR to NAM

doi: 10.1038/s42255-024-01191-9 157 KleniewskaPHoffmannAPniewskaEPawliczakR

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To confirm that the effects on DA Gsta4 OPC differentiation upon extended in vitro expansion were dependent on Gsta4 we performed knock-down of Gsta4 using siRNAs