MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 S)-AHPC-CO-PEG3-C2-azide Synonyms CAS Number n/a

S)-AHPC-CO-PEG3-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C31H45N7O7S Molecular Weight 659

1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CAS Number 2736497-81-5  Related CAS Molecular Formula C17H20N2O4 Molecular Weight 316

[O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

167 SMILES [2H]C([2H])([2H])OC1=CC=C(C=C1)C(O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 S)-AHPC-CO-PEG3-C2-azide Synonyms CAS Number n/aSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,