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In a clinical trial by Montenegro et al

However, a subsequent study revealed that CTSB contributes not only to the activation of trypsinogen within acinar cells but also within infiltrating macrophages, thereby exacerbating pancreatitis through NF-B nuclear translocation and the production of inflammatory mediators

NPs facilitate a regulated drug release, reducing the dosage frequency and improving patient compliance [130]

One open-label study found no benefits in terms of clinical outcomes (including fatigue) or oxidative stress with CoQ10 (as ubiquinol), 150 mg per day for 8 weeks