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doi: 10.1016/j.ecoenv.2020.111654

First, melatonin appears most useful where oxidative load is high (e.g., PCOS, diminished ovarian reserve, repeat-poor response), aiming to improve oocyte/embryo competence rather than to replace first-line ovulation-induction strategies

Theyre known for their strong antioxidant and anti-inflammatory properties

These statements have not been evaluated by Health Canada or the FDA

Chronic constipation patients have reduced EC cell density, decreased 5-HT synthesis, and significantly lowered colonic tissue 5-HT concentrations (Coates et al., 2004)