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doi: 10.1172/JCI126078 123

found that Uncariae Ramulus Cum Uncis extracts reduced neuronal death and epileptiform discharges in hippocampal pyramidal neurons in KA TLE model

10.1002/iub.1262 IUBMB Life 153 PittsM

10.1016/0304-3835(93)90048-e 78 SungH.FerlayJ.SiegelR

Therefore, the use of mice with inducible double knockout for Jnk1/Jnk2 may be a valuable approach to address the role of JNK in APAP-mediated hepatotoxicity

Specifically, this involves an enhancement of H3K4me in the promoters of proinflammatory cytokine genes (TNF-, IL-6, and MCP-1) and a simultaneous decrease in H3K9me3 in MCP-1 and IL-6 promoters