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FIGURE 2 Safety No severe adverse effects were reported during the course of the study and none of the study subjects discontinued GlyNAC because of adverse effects

Chakravarthy M, Arguelles-Tello FA, Sun ALA, Elliott M, Acosta L, Rankin JE, et al

Interestingly, induction of c-MET phosphorylation was observed upon the blockade of PI3K/AKT signaling, confirming a negative control of c-MET activity by AKT and warranting clinical investigation to determine the significance of p-c-MET as an escape mechanism to AKT inhibitors (Fig

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