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[7] [8] Patients on clozapine should likewise avoid glycine unless supervised closely, as it may blunt clozapines efficacy

For example, a review by Gwyer and colleagues (2019) concluded that while studies have reported findings across experimental models, the majority of the evidence comes from laboratory and animal research

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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs