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In addition, DAMPs released during ferroptosis such as high mobility group box 1 (HMGB1) activate macrophages and Th17 cells, promoting the secretion of pro-inflammatory cytokines such as TNF-, IFN- and IL-17, thereby establishing a ferroptosis-inflammation positive feedback loop (see Figure 2 ) (109)

10.1016/j.cmet.2008.07.005 35 SenguptaR.HolmgrenA

[6] [19] The enzyme contains two active sites

Liposomes containing antioxidants are being studied for acute oxidant-related COPD

Glutathione antioxidant support for brighter-looking skin

Clinically, SSG levels of plasma proteins (e.g., serpin A1/A3) are associated with radiotherapy efficacy in prostate cancer, serving as potential biomarkers (96)