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Additionally, the ability to successfully apply this protocol to FRDA iPSC-NPCs and demonstrate the ability of ASOs to activate FXN expression, provides exciting evidence for the potential of synthetic oligonucleotides in FRDA gene therapy [67]

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Data are presented as the average standard error of the mean (SEM) from a minimum of three independent experiments

Mechanism of action : Perampanel is a selective, non-competitive AMPA-type glutamate receptor antagonist