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For instance, blocking lactate efflux via MCT4, using agents such as VB124, can redirect pyruvate toward mitochondrial oxidation, thereby conferring cardioprotection in myocardial IRI (193)

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Studies indicate that ingestion of caffeine (e.g., 39 mg/kg taken 3090 min before exercise) can spare carbohydrate use during exercise and thereby improve endurance exercise capacity [430, 431]

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