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Eseberri I, Lasa A, Churruca I, Portillo MP (2013) Resveratrol metabolites modify adipokine expression and secretion in 3T3-L1 pre-adipocytes and mature adipocytes

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Nature structural & molecular biology 20 , 447453, doi: 10.1038/nsmb.2505 (2013)

reported that the compound IMA-1, which disrupts the interaction between ALOX12 and ACC1 (acetyl-CoA carboxylase 1), can reduce NASH progression in mice and Cynomolgus macaques, 258 suggesting that the ALOX12-ACC1 complex may be a clinically viable target for the management of NASH