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The aim of this in vitro study is to investigate the effects on normal human dermal fibroblast synthesis of collagen I and elastin, release of transforming growth factor- (TGF-), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinases (MMP), MMP-1 and MMP-3, and elastin degradation of collagen bioactive peptides, alone and in combination with other bioactive compounds found in two different collagen-based nutraceutical supplements previously reported to increase skin elasticity in vivo 28,29

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The small tetrapeptide size (~390 Da) makes Epithalon subject to rapid enzymatic cleavage and renal clearance

The liver is an organ filled with blood vessels that rely on angiogenesis for cellular regeneration (Whittaker et al., 2010)

The consequences of today's decisions therefore extend beyond the handful of peptides currently under review

TNF- increased the expression of CD15 and E-selectin adhesion molecules by hCMEC/D3 monolayers