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Concerning histone modifications, granulosa cells from PCOS patients exhibit enhanced histone deacetylase (HDAC) activity, which decreases acetylation levels of pro-inflammatory cytokines ( e.g ., TNF-, IL-6) and suppresses their transcriptional activation

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Inhalation of nanoparticles containing recombinant IL-17RC protein encapsulated in chitosan (CS-RC) led to a reduction in airway inflammation in asthma characterized by the Th2-low endotype, sometimes known as "severe asthma," predominantly through neutrophil infiltration and the IL-17 pathway [75]

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GSSG is potentially toxic to the cells but cells normally contain high glutathione reductase activity, which maintain most of the GSH in the reduced form