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In the same group, B12-downregulated genes had GO annotations related to NF-kappaB signaling, T-cell receptor signaling pathway and negative regulation of histone H3-K9 trimethylation ( Figure S3 )

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Diamantopoulos EJ, Andreadis EA, Tsourous GI, Katsanou PM, Georgiopoulos DX, Nestora KC, Raptis SA

Routine supplementation with folic acid (the synthetic form of folate) is universally recommended

Baseline characteristics among the three groups were well-matched for age, gender, body mass index, duration since diagnosis, prior use of any therapies (DMARDs, biologics, steroids) and clinical scores indicating disease activity