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3.3 Interventions to regulate mitophagy Mitophagy, a key quality control mechanism, plays a dual role in maintaining chondrocyte homeostasis: moderate activation eliminates dysfunctional mitochondria and interrupts the ROS-inflammation-cell death cycle, whereas defective or excessive autophagy accelerates OA progression

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Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism