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For example, CNF-1 was reported to induce inflammatory responses and produce chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 3 (MIP-3) (Munro et al., 2004)

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Preclinical studies demonstrated that the compound effectively inhibited KDAC activity under low-oxygen conditions, leading to DNA damage, cell-cycle arrest, and apoptosis in cancer cells

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