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doi: 10.1074/jbc.M302227200 13 Werner-FelmayerGGoldererGWernerE

in rabbit, proximal tubule had highest level of UGTs

Perhaps intermittent dosing or localized delivery (e.g., enema formulations for UC) could mitigate risks

Vi cng thc ti u, hm lng glutathione cao , sn phm mang n hiu qu lm trng da vt tri, ng thi nui dng ln da khe mnh v chng lo ha t bn trong

But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address