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Follmer C

Accumulation of ketone bodies in the blood vessels induces neutrophilic inflammation (239)

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Research in animal models has shown promising results for gut inflammation, wound healing, and skin conditions

Similar observations have been made in other disease models with high muscle glycogen, in which PGC-1 failed to promote an improvement or even worsened the outcome, e.g., Pompe disease (Takikita et al, 2010) or mice with an ablation of the mammalian target of rapamycin complex 1 (mTORC1) (Romanino et al, 2011)