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Taking into consideration the similarity between porcine and human thyroid (volume, the process of thyroid hormone synthesis) [171], it may be estimated that the concentration of iodine in porcine thyroidbroadly used in in vitro studiesis similar

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DOI: 10.1210/jcem.87.2.8182

Critically, in vitro binding or degradation does not guarantee efficacy in vivo due to the complex gastrointestinal environment, including variable pH, proteolytic enzymes, bile salts, and competition from resident microbiota (30, 94)