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COMT breaks down: Dopamine Norepinephrine Epinephrine (adrenaline) Estrogen (specifically catechol estrogens) Catechols from diet This means COMT is deeply connected to: Mood, motivation, and emotional stability (dopamine) Stress response and recovery (norepinephrine, epinephrine) Hormone balance and reproductive health (estrogen) Pain perception and sensitivity (dopamine and norepinephrine modulate pain pathways) Cognitive function and working memory (prefrontal cortex dopamine levels) When COMT is dirty: Fast COMT: Too little dopamine, norepinephrine in the synapse = low motivation, poor focus, flat mood, need for stimulation

10.18632/aging.100975 258 XuH.LiuY.-Y.LiL.-S.LiuY.-S

Like all human cells, the cells of your eyes are full of structures called mitochondria that produce energy for the cell to function

P.Hoek1996199685101 50

CHRIS: Our livers do indeed make far more cholesterol than we eat in the diet

10.1042/CBI20110304 52