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Increased GPX4 expression levels were confirmed in activated CD8 + T cells after transfection with a PiggyBac transposon system (Figure 2, K and L)

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Intra-articular injection of UC-MSC-Exos in OA rat models reduced the levels of cytokines (TNF-, IL-1, and IL-6) in the synovial fluid, decreased the expression of MMP-13 and ADAMTS-5 in chondrocytes stimulated by IL-1, and increased the expression of Col2 in chondrocytes, thereby promoting cartilage regeneration

Xiao W, Jiang W, Chen Z et al (2025) Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines

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