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Resting T-cell lysosomes and endosomes contain C3, and its cleavage by the CTSL to generate tonic intracellular C3a is critical in maintaining homeostatic T-cell survival

Proteostasis resilience: a systems-level perspective Together, these functional, spatial and adaptive properties define what can be conceptualized as proteostasis resilience, the capacity of cells, tissues and organisms to sustain proteome integrity despite acute or chronic stress

High levels of KAP1 expression are associated with aggressive clinical features in ovarian cancer

To hinder the host translation process, nsp1 is proposed to function by two mechanisms: the first is to bind the ribosomal 40S subunit during the initiation stage 64 and the second is to induce host mRNA degradation 65

Furthermore, lipophilic complexes facilitate intestinal absorption while shielding polyphenols from adverse interactions or breakdown during the digestive process (131)

J Biol Chem 274: 3321333219