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Journal of Cosmetic Dermatology, januari 2019, pagina's 728-737 4

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These results highlight the potential harmful effects of microplastic exposure on cognitive outcomes in children ( Polyethylene terephthalate (PET) nanoparticles accelerate amyloid fibril formation and alter the secondary structure of A fibrils, these findings further suggest that accumulation of PET nanoparticles in the brain promotes the progression of multiple neurodegenerative diseases, including Alzheimers disease ( Transmission electron microscopy and molecular dynamics simulations demonstrated that polystyrene nanoplastics accelerate A aggregation through the formation of protein coronas, facilitating peptide fibrillization via hydrogen bonding and interactions, flow cytometry and endocytosis inhibition assays revealed that polystyrene nanoplastics impair microglial uptake of A while enhancing their own cellular internalization, leading to microglial energy exhaustion and allowing A aggregates to escape immune clearance

To produce homozygous Csnk1e -KO x hTDP-43-NLS mice, homozygous Csnk1e -KO mice were bred with each parent line of the hTDP-43-NLS mouse model which were the hemizygous NEFH-tTA mice and hemizygous tetO-hTDP-43-NLS mice