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In addition, Matesanz-Snchez et al.s study showed that a decrease in EXT2 levels can cause dysregulation of lipid metabolism and antioxidant capacity by altering SAM and transsulfuration pathway enzymes levels, triggering lipid peroxidation and ultimately leading to ferroptosis in GBM cells [12]

The MDA content was determined on a fresh weight basis as follows: Data were calculated as nmoles per gram dry weight (nmol g 1 dw)

For instance, rapamycin, initially discovered as an antifungal agent, has now been extensively studied for its anti-cancer properties (Weng and Goel, 2022)