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Cracking the PROTAC Permeability Barrier: CD36-Mediated Endocytosis as a Potential Breakthrough 2025-12-03 In recent years, proteolysis-targeting chimeras (PROTACs) have shown tremendous promise in targeting "undruggable" proteins

An amino acid found in the human body that is an active and important compound involved in the metabolism of many organisms

S100 proteins are typically symmetric dimers, and each subunit contains two helix-loop-helix EF-hand motifs that are separated by a flexible hinge region and flanked by conserved hydrophobic residues at the amino- and carboxy-terminal ends (34) ( Figure 1 )

By integrating these findings, this review offers new insights into the role of ferroptosis in joint degeneration and highlights its potential as a therapeutic target in osteoarthritis

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This receptor works to clear IGF-II and its presence in endothelial cells may, at least partly, explain the lack of endocrine actions of IGF-II due to its proteolytic lysosomal degradation (23)