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3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA

Curcumin crosses the blood-brain barrier and is known to help reduce oxidative stress, improve mood and potentially reduce the risk of Alzheimers disease by clearing amyloid plaques

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Oncogene (1999) 18(45):610411

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Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study)