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This drop happens in almost all tissues and follows a clear pattern

10.3390/antiox10091353 39 BuglioD

IV therapy works its magic through multiple pathways

In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80