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The question then arises: What is the explanation for this unique apparent regulation of Se-GSH-Px by organic selenium? Regulation of the GSH-Px system The glutathione (GSH) system, comprising oxidized and reduced GSH and the two enzymes GSH peroxidase and GSH reductase, is closely related to the metabolism of two amino acids, cysteine (Cys) and methionine (Met) (Figure 3) via the key intermediary metabolite, homocysteine

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Moreover, another study indicated that the following a diet with high omega-3 and low omega-6 fatty acids in comparison to a diet with low omega-6 had desirable effects on pain, quality of life, and antinociceptive lipid mediators in migraine patients (136)