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Mutations in genes encoding amyloid beta precursor protein (APP) and presenilins 1 and 2 are characteristic of the familial type of AD and lead to the aberrant processing of APP and the production of amyloid- peptides that aggregate into senile plaques extracellularly

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Moreover, the chelation process can not only form a four membered ring on its carboxyl group, but also form a six membered ring on hydroxyl and carboxyl groups

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