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Methods Neurosci

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These nutraceuticals have some mechanisms of action in common, including the inhibition of ACE, the enhancement of NO-mediated vasodilation, interactions with ion channels including the blocking of calcium channels and opening of potassium channels with consequent membrane hyperpolarization, anti-inflammatory effects with reductions in synthesis and release of pro-inflammatory cytokines, and enhancement of endogenous antioxidant actions exerted by different enzymes, such as SOD, GPx, and GSTP