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doi: 10.1186/1824-7288-40-S1-A15 115

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With age, SIRT1 levels decline, disrupting the molecular clock in the SCN and thereby impairing both circadian and metabolic homeostasis (Chang and Guarente, 2013

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During sleep, the hippocampus replays and consolidates memories formed during the day, a process that requires BDNF signaling