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Coumestrol, a bioactive found in legumes, was also described for its ability to increase mitochondria biogenesis in cultured muscle cells underlined by an upregulation of electron transport chain proteins and transcriptional regulator of mitochondria biogenesis: PGC 1 and NFR-1 (Seo et al., 2014)

Normal neurons displayed round or oval nuclei with prominent nucleoli, while damaged neurons exhibited pyknotic or fragmented nuclei and cytoplasmic vacuolization 24

Confirmatory in vivo experiments further demonstrated that the overexpression of MKL-1 in gastric cancer cells indeed resisted the onset of Erastin-induced ferroptosis (Figure S4C-F)

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There was no significant difference in the expression of PR protein between groups ( p = 0.796) (Fig

Lipid rafts: Buffers of cell membrane physical properties