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A dental examination with appropriate preventive dentistry should be considered prior to treatment with bisphosphonates in patients with a history of concomitant risk factors (e.g., cancer, chemotherapy, angiogenesis inhibitors, radiotherapy, corticosteroids, poor oral hygiene, preexisting dental disease or infection, anemia, coagulopathy)

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Current evidence suggests PT-141 is safe for ongoing as-needed use when administered appropriately

doi: 10.1016/j.progpolymsci.2011.08.005 124 MuraliV

Umfangreiche In-vitro-Studien haben seine biologische Stabilitt und Vertrglichkeit demonstriert