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Animal 15, 100366

doi: 10.3390/biom11020185 53 PhebyDFHFriedmanKJMurovskaMZalewskiP

Particularly, the pro-inflammatory cytokine TNF- is widely known to be a proximal mediator of hepatocyte apoptosis and necrosis in inflammatory DILI 48,49 , which could have contributed to hepatic injury in the model