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Concomitantly, as pharmacological NPC1 inhibition leads to a reduction in esterified cholesterol due to the lack of cholesterol transport to the ER, this likely contributes to the moderate increase in total cellular cholesterol levels determined biochemically when compared to controls (Supplementary Fig

Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)

They "recycle" each other

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The connection to NAD+ biology adds another dimension of interest

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