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xCT, also known as SLC7A11, is a cystine/glutamate antiporter that exports intracellular glutamate in exchange of equimolar extracellular cystine [78]

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Under oxidative stress, Nrf2 is released from Keap1 and translocated to the nucleus, where it binds to the antioxidant response element (ARE) and upregulates the expression of NQO1 and HO-1 (Meng et al., 2014)

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