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Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients

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239,240 This activation increases the expression of proinflammatory cytokines and adhesion molecules, contributing to oxidative stress, inflammation, and vascular dysfunction

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They span approximately 2 to 100 amino acids, with most therapeutic peptides comprised of 2 to 20 residues connected like beads on a string