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52 In the liver, SIRT1 plays a central role at the intersection of lipid metabolism, insulin sensitivity, and inflammatory signaling, coordinating metabolic adaptation through a network of regulatory pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Galloway DC, McLellan LI

Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer

Collectively, our results highlight a critical role of ABCC4 in lipid metabolism through cAMP-Epac2/Rap1a signaling, which restrains hepatic PCSK9 protein levels, thereby facilitating LDLR surface availability and promoting clearance of circulating LDL-C

135 Dihydroartemisinin can significantly inhibit the viability of leukemia cells, causing cell cycle G0/G1 phase arrest and ferroptosis, and the mechanism may be related to inducing autophagy and accelerating ferritin degradation by regulating AMP-activated kinase (AMPK)/mTOR/p70S6k signaling pathway

Considering the fact that tumour microenvironment stresses are strong inducers of the endoplasmic reticulum stress (Murakami et al, 2007), the FASN inhibitors could show selective and enhanced cytotoxicity to cancer cells under the tumour microenvironment conditions