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Some evidence suggests RLS patients may have a defect in iron transport across the blood-brain barrier, possibly related to genetic factors (Wade 2019

It has been shown that mitochondria-free axon terminals of hippocampal or cortical neurons accumulate more Ca 2+ in response to repetitive stimulation, which promotes increasingly more SV release [55, 56]

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Furthermore, the study showed that PCs curtail cell proliferation induced by glucose, insulin, and palmitate, although the precise mechanism remains unclear

Accelerometer data indicated that the long COVID patients were not bed-ridden, and had an average step-count of ~4000 steps/day (Supplemental Fig