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Phosphorylation increases the enzymes fructose 2,6-bisphosphatase activity while decreasing its phosphofructokinase-2 activity

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The diversity of mechanisms is a strength, not a complication

These constraints can be mitigated by anchoring point-of-care readouts to validated lab assays, implementing specificity controls (e.g., SOD/catalase for O 2 /H 2 O 2 , chelators for Fenton dependence), and using compartment-targeted, ratiometric reporters with documented calibration (Krl and Brzenicki 2023