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However, "unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body," according to Merck Manuals Consumer Version

In studies on vitamin E, supplementation reduced kidney and cell damage and inflammation, especially with omega 3 fatty acids from fish oil (x, x)

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This implies that a significant proportion of patients with diabetes who regularly use metformin take acid-suppressing medications, potentially increasing the risk of developing a vitamin B12 deficiency [17,50]

Vitamin B12 is also a vital nutrient for brain development, both during pregnancy and in early infancy