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Antibodies used: anti-IL-6 (1:50, Proteintech, 21865-1-AP), anti-occludin (1:100, Proteintech, 13409-1-AP), anti-Muc2 (1:100, Proteintech, 27675-1-AP), anti-Ki67 (1:250, Abcam, ab16667), anti-LGR5 (1:400, Affinity, DF2816) and anti-HMGCS2 (1:100, ABclonal, A14244)