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(2023c, April 27)

Researchers should expect attenuated rather than equivalent effects when extrapolating from preclinical data to human application

Dose adjustment, a temporary pause, or a switch to oral semaglutide may be appropriate

The direct and weight-independent actions of some new obesity pharmacotherapies in ectopic fat of specific organs may further enhance the potential for tailored treatment choices based on patients complications

(5) Notably, this stimulation seems selective for collagen, as non-collagen protein synthesis apparently remained unaltered, suggesting the action may not have been a general support for protein production