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In general, major treatments are not recommended for mild GO, unless there is a sufficient impairment in the quality of life, which justifies the risk of GC-related adverse events (58, 6466)

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The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling