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J Neural Transm 112:789796 Ueno Y, Koike M, Shimada Y, Shimura H, Hira K, Tanaka R, Uchiyama Y, Hattori N, Urabe T (2015) l-Carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain

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There are two categories, based on where the abnormal brain activity beginsgeneralized seizures and partial (focal) seizures

Production of ROS from the mitochondrial action is physiologic, but dysfunction of ETC in damaged mitochondrial causes excessive ROS production, which is quite detrimental to cells

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Also, it should be kept in mind that strategies to counteract the detrimental impacts of RAGE signaling should preserve beneficial effects of RAGE