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Mechanism of Action NSAIDs inhibit one or both COX enzymes: COX-1 Protects gastric mucosa Maintains renal blood flow Supports platelet aggregation COX-2 Induced during inflammation Produces prostaglandins involved in pain, swelling, and fever Traditional NSAIDs block both COX-1 and COX-2

Current literature emphasizes preliminary and model-based observations rather than definitive conclusions

To prevent the movement of intestinal contents, zip ties were used to mark and isolate sample locations before collection

At The Sculptique Aesthetics we do not recommend self-dosing - our clinicians determine dose , frequency and cycle after a full consultation

D., & Watowich, S