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The biotransformation of oxaliplatin from reactions with cysteine, glutathione, and methionine at physiological pH has shown that oxaliplatin complexes could be formed via direct displacement of the labile leaving ligand without prior aquation 31,32

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At the same time, the complexity and multifunctionality of the tryptophan metabolic network provide diverse intervention targets for the treatment of chronic diseases

A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I