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However, despite their health benefits, the low absorption rate of polyphenols (approximately 510% via the small intestine) and their rapid metabolism and excretion significantly limit their ability to reach target tissues (114)

ATRX deficiency has been shown to accelerate GBM growth and reduce survival, linking ATRX loss to DNA repair deficiencies, particularly impaired nonhomologous end joining

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The radiosensitization potential of coated NPs is confirmed by numerous studies but in most of them, the coating layer is mostly applied to reduce toxicity of the NPs and for stability and biocompatibility aims

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